Tetracaine hydrochloride
| Code | Size | Price |
|---|
| CDX-T0453-G005 | 5 g | £48.00 |
Quantity:
| CDX-T0453-G025 | 25 g | £78.00 |
Quantity:
| CDX-T0453-G050 | 50 g | £126.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester; Amethocaine hydrochloride
Appearance:
White to off-white powder.
CAS:
136-47-0
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS06
Handling Advice:
Protect from light and moisture.
Hazards:
H301, H317, H319
InChi:
InChI=1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H
InChiKey:
PPWHTZKZQNXVAE-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 136-47-0. Formula: C15H24N2O2 . HCl. MW: 264.4 . 36.5. Synthetic. Tetracaine is a potent local anaesthetic and a channel function allosteric inhibitor that blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. inhibitor of voltage-gated sodium channels such as NaV1.4 and NaV1.8. Shown also to reversibly block nicotinic acetylcholine (ACh) receptors (nAChRs).
MDL:
MFCD00038912
Molecular Formula:
C15H24N2O2 . HCl
Molecular Weight:
264.4 . 36.5
Package Type:
Vial
PG:
III
Precautions:
P261, P264, P270, P272, P280, P301+P310, P302+P352, P305+P351+P338, P321, P330, P333+P313, P337+P313, P363, P405, P501
Product Description:
Tetracaine is a potent local anaesthetic and a channel function allosteric inhibitor that blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. inhibitor of voltage-gated sodium channels such as NaV1.4 and NaV1.8. Shown also to reversibly block nicotinic acetylcholine (ACh) receptors (nAChRs).
Purity:
>99% (TLC)
Signal word:
Danger
SMILES:
CCCCNC1=CC=C(C(OCCN(C)C)=O)C=C1.Cl
Solubility Chemicals:
Soluble in water (40mg/ml), DMSO (40mg/ml) or ethanol (20mg/ml).
Source / Host:
Synthetic
Transportation:
Excepted Quantity
UN Nummer:
2811
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) S. Hishinuma & M.K. Uchida; Br. J. Pharmacol. 103, 1393 (1991) | (2) L. Desmedt, et al.; J. Gen. Physiol. 101, 103 (1993) | (3) E. Jaimovich & E. Rojas; Cell Calcium. 15, 356 (1994) | (4) S. Gyoerke, et al.; J. Physiol. 500, 297 (1997) | (5) C.L. Overend, et al.; J. Physiol. 502, 471 (1997) | (6) D. Mears, et al.; Cell Calcium 25, 59 (1999) | (7) R. Cobo, et al.; Front. Mol. Neurosci. 11, 193 (2018)