Tianeptine sodium salt
| Code | Size | Price |
|---|
| CDX-T0456-M500 | 500 mg | £164.00 |
Quantity:
| CDX-T0456-G001 | 1 g | £267.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide sodium salt; S-1574; Stablon
Appearance:
White to pale yellow solid.
CAS:
30123-17-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep under inert gas.Very hygroscopic.
InChi:
InChI=1S/C21H25ClN2O4S.Na/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);/q;+1/p-1
InChiKey:
ZLBSUOGMZDXYKE-UHFFFAOYSA-M
Long Description:
Chemical. CAS: 30123-17-2. Formula: C21H24ClN2O4S . Na. MW: 435.9 . 23.0. Synthetic. Tianeptine is an atypical antidepressant with diverse actions, most notably on the glutamatergic system. It is a selective facilitator of 5-HT (serotonin) uptake in vitro and in vivo. It attenuates glutamate release and modulates the function of the AMPA receptor. Tianeptine also acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641nM for human and mouse receptors, respectively). Might have anti-inflammatory properties through modulation of TLR and NLRP3 inflammasome signaling pathways.
MDL:
MFCD00879851
Molecular Formula:
C21H24ClN2O4S . Na
Molecular Weight:
435.9 . 23.0
Package Type:
Vial
Product Description:
Tianeptine is an atypical antidepressant with diverse actions, most notably on the glutamatergic system. It is a selective facilitator of 5-HT (serotonin) uptake in vitro and in vivo. It attenuates glutamate release and modulates the function of the AMPA receptor. Tianeptine also acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641nM for human and mouse receptors, respectively). Might have anti-inflammatory properties through modulation of TLR and NLRP3 inflammasome signaling pathways.
Purity:
>98% (T)
SMILES:
ClC(C=C1)=CC2=C1C(NCCCCCCC([O-])=O)C(C=CC=C3)=C3N(C)S2(=O)=O.[Na+]
Solubility Chemicals:
Soluble in DMSO (20mg/ml), DMF (30mg/ml), ethanol (10mg/ml) and water (10mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) T. Mennini, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 336, 478 (1987) | (2) R. Defrance, et al.; Clin. Neuropharmacol. 11, S74 (1988) (Review) | (3) M.G. Simoni, et al.; Brain Res. 574, 93 (1992) | (4) I.T. Uzbay, et al. ; Life Sci. 64, 1313 (1999) | (5) A.J. Wagstaff, et al.; CNS Drugs 15, 231 (2001)| (6) F. Plaisant, et al.; Neuropharmacol. 44, 801 (2003) | (7) B.S. McEwen, et al. ; Mol. Psych. 15, 237 (2010) | (8) V. Szegedi, et al.; Neurochem. Int. 59, 1109 (2011) | (9) S.S. Bilge, et al.; Eur. J. Pharmacol. 681, 44 (2012) | (10) H. Zhang, et al.; Mol. Psych. 18, 471 (2013) | (11) M.M. Gassaway, et al.; Transl. Psych. 4, 1 (2014) | (12) D. Jantas, et al.; Neurotox. Res. 25, 208 (2014) | (13) M.K. Seo, et al.; Psychopharmacol. 233, 2617 (2016) | (14) J. Slusarczyk, et al.; Int. J. Mol. Sci. 19, E1965 (2018)