Rabbit anti Human Neurogenin-1
| Code | Size | Price |
|---|
| EXA-X2758P | 100 ug | £316.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme Immunoassay (EIA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ship at ambient temperature freeze upon arrival
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
Antibody can be used for immunohistochemical staining (1-5 ?g/ml). Optimal concentration should be evaluated by serial dilutions.
Background:
Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Efficient DNA binding requires dimerization with another bHLH protein. Expression restricted to the embryonic nervous system.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Neuroscience
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Immunohistochemistry
Immunogen:
Synthetic peptide derived from human neurogenin-1 protein.
Product Form:
Affinity Purified
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Antigen Immunoaffiinity Purification
Synonyms:
Class A basic helix-loop-helix protein 6; Neurogenic basic-helix-loop-helix protein; Neurogenic differentiation factor 3; NeuroD3; bHLHa6; NGN-1
UniProt:
Q92886
References
1. Velkey, J.M., et al. ?Expression of Neurogenin 1 in Mouse Embryonic Stem Cells Directs the Differentiation of Neuronal Precursors and Identifies Unique Patterns of Down-stream Gene Expression.? Dev. Dyn., 242, 230-253 (2013)
2. Hill, G.W., et al. ?Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1.? Stem Cells Dev., 21, 2827-2837 (2012)
3. Choi, C.I., et al. ?Neural Induction with Neurogenin 1 Enhances the Therapeutic Potential of Mesenchymal Stem Cells in an ALS Mouse Model.? Cell Transplant., Epub ahead of print (2012)
2. Hill, G.W., et al. ?Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1.? Stem Cells Dev., 21, 2827-2837 (2012)
3. Choi, C.I., et al. ?Neural Induction with Neurogenin 1 Enhances the Therapeutic Potential of Mesenchymal Stem Cells in an ALS Mouse Model.? Cell Transplant., Epub ahead of print (2012)