Rabbit anti Human PINK1 (N-Terminal)
| Code | Size | Price |
|---|
| EXA-X2759P | 100 ug | £316.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme Immunoassay (EIA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ship at ambient temperature freeze upon arrival
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
Antibody can be used for immunohistochemical staining (1-5 ?g/ml). Optimal concentration should be evaluated by serial dilutions.
Background:
Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Neuroscience
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Immunohistochemistry
Immunogen:
Synthetic peptide derived from the N-terminal of the human PINK1 protein.
Product Form:
Affinity Purified
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Antigen Immunoaffiinity Purification
Synonyms:
PTEN-induced putative kinase protein 1
UniProt:
Q9BXM7
References
1. Matsuda, N., et al. ?PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.? J. Cell. Biol., 189, 211-221 (2010)
2. Vives-Bauza, C., et al. ?PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.? Proc. Natl. Acad. Sci. USA, 107, 378-383 (2010)
3. Valente, E.M., et al. ?PINK1 mutations are associated with sporadic early-onset parkinsonism.? Ann. Neurol., 56, 336-341 (2004)
4. Song, S., et al. ?Characterization of PINK1 (PTEN-induced Putative Kinase 1) Mutations Associated with Parkinson Disease in Mammalian Cells and Drosophila.? J Biol Chem. 288(8): 5660-5672, (2013)
2. Vives-Bauza, C., et al. ?PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.? Proc. Natl. Acad. Sci. USA, 107, 378-383 (2010)
3. Valente, E.M., et al. ?PINK1 mutations are associated with sporadic early-onset parkinsonism.? Ann. Neurol., 56, 336-341 (2004)
4. Song, S., et al. ?Characterization of PINK1 (PTEN-induced Putative Kinase 1) Mutations Associated with Parkinson Disease in Mammalian Cells and Drosophila.? J Biol Chem. 288(8): 5660-5672, (2013)