Rabbit anti Human Cysteine string protein (CSP) Alpha DNAJC5 alpha

Antibody can be used for immunohistochemistry (5-10 ?g/ml). Optimal concentration should be evaluated by serial dilutions.

May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. The amino terminus of CSP contains the J domain, a consensus sequence found on a DnaJ like protein which is a member of the heatshock protein family. Since heat shock proteins serve as chaperones that participate in protein folding and protein complex formation, CSP is believed to perform similar functions in the assembly of synaptic vesicle proteins which are essential to membrane trafficking. Evidence for a role of CSP in presynaptic neurotransmitter release has come from genetic and physiological study in which the Drosophila CSP null mutant fails to elicit synaptic potential upon high frequency stimulation. CSP null mutants have a lethal phenotype and for the small percentage of mutant flies that survive, they become paralyzed and die at elevated temperature.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

See vial for concentration

Neuroscience

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Western Blotting

Synthetic peptide derived from the human CSP protein.

Human brain; Expressed in tissue of pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart

Unconjugated

Products are stable for one year from purchase when stored properly

Ammonium Sulfate Precipitation

CSP, DnaJ homolog subfamily C member 5

Q9H3Z4