Nordic MuBio

FBXW7

Product Code:
 
EXA-X2337B
Product Group:
 
Peptides
Supplier:
 
Nordic MuBio
Host Type:
 
Rabbit
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Ship at ambient temperature freeze upon arrival
Storage:
 
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
 

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EXA-X2337B50 ug£162.00
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Further Information

Applications Description:
For use with FXBW7 polyclonal antibodies (Cat. No. X2314P & X2336P).
Background:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide dervied from the human FBXW7 protein
Positive Control:
Widely expressed in most human tissues.
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Synonyms:
F-box and WD-40 domain protein 7, FBXW7, CDC4
UniProt:
Q969H0

References

1. Strohmaier, H., et al. 'Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.; Nature 413:316-322(2001).

2. Moberg, K.H., et al. 'Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines.; Nature 413:311-316(2001).