Zinc Finger Protein GLI1
| Code | Size | Price |
|---|
| EXA-X2367B | 50 ug | £162.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Regulatory Status: RUO
Target Species: Human
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
For use with zinc finger protein GLI1 polyclonal antibodies (Cat. No. X2363P & X2366P).
Background:
Zinc Finger Protein GLI1 is a member of the Kruppel family of zinc finger proteins. It is thought that it may regulate the transcription of specific genes during normal development and may play a role in craniofacial development and digital development. It also may be involved in the development of the central nervous system and gastrointestinal tract. This protein mediates SHH signaling and thus cell proliferation and differentiation. It has been localized to the cytoplasm and nucleus. It is tethered in the cytoplasm by binding to SUFU and activation and translocalization to the nucleus is promoted by interation with STK36. Protein expression is amplified in glioblastoma cells. Defects in the GLI1 protein may be a cause of breast cancer.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Formulation:
Provided as solution in phosphate buffered saline
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Synonyms:
Glioma-associated oncogene; Oncogene GLI
UniProt:
P08151 (Human)