Rabbit anti Human Lass1 (non-GDF1)
| Code | Size | Price |
|---|
| EXA-X2311P | 100 ug | £316.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
Ship on gel ice store at -20°C immediately upon arrival
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
Antibody can be used for Western blotting (1:400 starting dilution). Other uses not yet tested. Only reacts with human Lass1 protein. Does not cross react with other species. Optimal concentration should be evaluated by serial dilutions.
Background:
LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The human homolog of LAG1 has functions in human aging. LAG1 may be involved in neurodegenerative diseases and human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane; LAss1 is a multi-pass membrane protein.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
Lot specific, see vial
Field of Interest:
Lipid Mediators
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide derived from the human Lass1 protein.
Positive Control:
Hypothalamus
Product Form:
Affinity Purified
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Antigen Immunoaffiinity Purification
Synonyms:
LAG1 longevity assurance homolog 1, UOG-1 protein, LASS1
UniProt:
P27544
References
[1] Lee S.-J.; Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.; Proc. Natl. Acad. Sci. U.S.A. 88:4250-4254(1991).
[2] Jiang J.C., Kirchman P.A., Zagulski M., Hunt J., Jazwinski S.M.; Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.; Genome Res. 8:1259-1272(1998).
[3] Grimwood J., et al.; The DNA sequence and biology of human chromosome 19.;
Nature 428:529-535(2004).
[4] The MGC Project Team; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).; Genome Res. 14:2121-2127(2004).
[2] Jiang J.C., Kirchman P.A., Zagulski M., Hunt J., Jazwinski S.M.; Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.; Genome Res. 8:1259-1272(1998).
[3] Grimwood J., et al.; The DNA sequence and biology of human chromosome 19.;
Nature 428:529-535(2004).
[4] The MGC Project Team; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).; Genome Res. 14:2121-2127(2004).