Rabbit anti Human Monocarboxylate Transport 2
| Code | Size | Price |
|---|
| EXA-X2371P | 100 ug | £316.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Shipping:
Ship at ambient temperature freeze upon arrival
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
Antibody can be used for Western blotting (1:400 starting dilution). Optimal concentration should be evaluated by serial dilutions.
Background:
Functions as a proton-linked monocarboxylate transporter and catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a very high affinity pyruvate transporter. MCT2 is a cell membrane; Multi-pass membrane protein with high expression in testis, moderate to low expression in spleen, heart, kidney, pancreas, skeletal muscle, brain and leukocytes. The normal expression of MCT2 is restricted to low levels of expression in normal tissues, but is widely expressed in cancer cells.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Lipid Mediators
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide derived from human MCT2 protein
Positive Control:
Testis, spleen, heart, kidney, pancreas, skeletal muscle, brain and leukocyte.
Product Form:
Affinity Purified
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Ammonium Sulfate Precipitation
Synonyms:
MCT2; Solute carrier family 16 member 7; SLC16A7
UniProt:
O60669 (Human)
References
1: Dao L., Landschulz W.H., Landschulz K.T.; Cloning of human monocarboxylate transporter 2 (hMCT2). Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
2: Lin R.-Y., Vera J.C., Chaganti R.S.K., Golde D.W.;
Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter.;
J. Biol. Chem. 273:28959-28965(1998).
2: Lin R.-Y., Vera J.C., Chaganti R.S.K., Golde D.W.;
Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter.;
J. Biol. Chem. 273:28959-28965(1998).