Rabbit anti Human Lass4

Product Code: EXA-X2300P

Code	Size	Price

EXA-X2300P

100 ug

£316.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit

Antibody Clonality: Polyclonal

Regulatory Status: RUO

Target Species: Human

Shipping:

Ship at ambient temperature freeze upon arrival

Storage:

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Further Information

Applications Description:

Antibody can be used for Western blotting (1 mg/ml starting dilution). Optimal concentration should be evaluated by serial dilutions.

Background:

It is thought that Lass4 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.

Caution:

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

Concentration:

See vial for concentration

Formulation:

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Functional Analysis:

Western Blotting

Immunogen:

Synthetic peptide derived from human Lass4 protein.

Positive Control:

Lung and embryo

Product Form:

Unconjugated

Product Stability:

Products are stable for one year from purchase when stored properly

Purification Method:

Ammonium Sulfate Precipitation

UniProt:

Q9HA82

References

1. Min, J., et al. '(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1.' Mol. Cancer Res. 2007, 5(8):801-812

2. Ruckhaberle, E., et al. 'Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.' Breast Cancer Res Treat. 2007 Dec 4 [Epub ahead of print]