Rabbit anti Human PH domain leucine-rich repeat-containing protein phosphatase 2

This antibody can be used for immunohistochemistry on formalin/paraffin sections (10-15 ?g/ml). Optimal concentration should be evaluated by serial dilutions.

PHLPP2 is a protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

See vial for concentration

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Immunohistochemistry

Synthetic peptide derived from the human PHLPP2 protein

Normal human kidney

Pure
Affinity Purified

Products are stable for one year from purchase when stored properly

Antigen Immunoaffinity Purification

PHLPP2, PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like

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