Rabbit anti Human FBXW7

Product Code: EXA-X2336P

Code	Size	Price

EXA-X2336P

100 ug

£316.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit

Antibody Clonality: Polyclonal

Regulatory Status: RUO

Target Species: Human

Shipping:

Ship at ambient temperature freeze upon arrival

Storage:

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Further Information

Applications Description:

Antibody can be used for Western blotting (1-5 ?g/ml). Optimal concentration should be evaluated by serial dilutions.

Background:

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.

Caution:

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

Concentration:

See vial for concentration

Formulation:

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Functional Analysis:

Western Blotting

Immunogen:

Synthetic peptide dervied from the human FBXW7 protein

Positive Control:

Widely expressed in most human tissues.

Product Form:

Unconjugated

Product Stability:

Products are stable for one year from purchase when stored properly

Purification Method:

Ammonium Sulfate Precipitation

Synonyms:

F-box and WD-40 domain protein 7, FBXW7, CDC4

UniProt:

Q969H0

References

1. Strohmaier, H., et al. 'Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.; Nature 413:316-322(2001).

2. Moberg, K.H., et al. 'Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines.; Nature 413:311-316(2001).