Rabbit anti Human PH Domain-containing family E member 1

Optimal concentration should be evaluated by serial dilutions.

PHLPP1 is a 1717 aa protein with phosphatase activity that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

See vial for concentration

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Immunohistochemistry

Synthetic peptide derived from the human PHLPP1 protein

Pure
Affinity Purified

Products are stable for one year from purchase when stored properly

Antigen Immunoaffinity Purification

KIAA0606, PHLPP, PLEKHE1, SCOP, PHLPP1, PH domain leucine-rich repeat-containing protein phosphatase 1; Pleckstrin homology domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein

O60346