Rabbit anti Human Ribonucleoside-diphosphate reductase large subunit (RRM1)

This antibody can be used for immunohistochemistry on formalin/paraffin sections (10-15 ?g/ml). Optimal concentration should be evaluated by serial dilutions.

This protein is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in the S phase of dividing cells. The gene for RRM1 is, along with several others, located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region are associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. RRM1 plays an important role in malignancies and disease that involve this region.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

See vial for concentration

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Immunohistochemistry

Synthetic peptide derived from the human RRM1 protein

Affinity Purified

Products are stable for one year from purchase when stored properly

Antigen Immunoaffinity Purification

Ribonucleoside-diphosphate reductase subunit M1, EC=1.17.4.1, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1

P23921