Rabbit anti Human Caveolin 1
| Code | Size | Price |
|---|
| EXA-X1863P | 100 ug | £316.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Shipping:
Ship at ambient temperature freeze upon arrival
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
Antibody can be used for Western blotting (1-5 ?g/ml). Optimal concentration should be evaluated by serial dilutions.
Background:
Caveolin 1 is a tyrosine phosphoprotein that plays an essential role in the formation of caveolae where it acts as a scaffolding protein. It has also been shown to bind cholesterol and to be involved in the lipid transport, membrane trafficking and signal transduction. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide derived from the human caveolin-1 beta isoform
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Ammonium Sulfate Precipitation
UniProt:
Q03135
References
1. Cai, T., et al. 'Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase.' J. Cell Biol. 2008, 182, 1153-1169.
2. Dittman, K., et al. 'Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK.' Mol. Cancer 2008, 7, 69.
3. Zhong, Y., et al. 'Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling.' J. Neurosci. 2008, 28, 7788-7796.
4. Tourkina, E., et al. 'Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo.' Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 294, L843-L861
5. Huang, J.H., et al. 'Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1.' J. Biol. Chem. 2007, 282, 6143-6152.
2. Dittman, K., et al. 'Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK.' Mol. Cancer 2008, 7, 69.
3. Zhong, Y., et al. 'Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling.' J. Neurosci. 2008, 28, 7788-7796.
4. Tourkina, E., et al. 'Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo.' Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 294, L843-L861
5. Huang, J.H., et al. 'Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1.' J. Biol. Chem. 2007, 282, 6143-6152.