Sheep anti-Cytochrome C
| Code | Size | Price |
|---|
| EXA-A195P | 200 ul | £295.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Sheep
Antibody Clonality: Monoclonal
Antibody Clone: Polyclonal
Regulatory Status: RUO
Target Species:
- Canine (dog)
- Human
- Rabbit
- Rat
Applications:
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
Western Blot|Immunoprecipitation|Immunohistochemistry
Background:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
Formulation:
Whole sheep antiserum, no carrier or preservative added.
Immunogen:
Full length recombinant Cytochrome
Positive Control:
Rat1 cell line; Mitochondrion matrix
Product:
Whole sheep antiserum, no carrier or preservative added.
Purification Method:
Whole Antiserum, no purification
UniProt:
P00011 (Canine), P00008 (Rabbit), P62898 (Rat), P99999 (Human)