Sheep anti Human Rhombotin 2

Western Blots at 1-10 ug /ml

Two homologues of the rhombotin gene have now been isolated. One of these, designated Rhom-2, is located on human chromosome 11 at band 11p13, where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene. Human and mouse Rhom-2 are highly conserved and, like rhombotin, encode two tandem cysteine-rich LIM domains. Rhom-2 mRNA is expressed in early mouse development in central nervous system, lung, kidney, liver, and spleen but only very low levels occur in thymus. The Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors. Chromosome bands 11p15 (rhombotin) and 11p13 (Rhom-2) are consistent sites of chromosome translocation in T-cell leukemia, with the 11p15 target more rarely involved.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

See vial for concentration

Inflammation & Immunology

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Western Blotting

Full length rhombotin 2 protein

Unconjugated

Antibodies are stable for one year from purchase if stored frozen

Ammonium Sulfate Precipitation

LIM domain only protein; cysteine-rich protein TTG-2; T-cell translocation protein 2

P25791 (Human)