Rabbit anti Human Protein Phosphatase 5 (C Terminal)

This antibody can be used for Western blotting (5-10 ?g/ml). Other applications being evaulated. Optimal concentration should be evaluated by serial dilutions.

Protein phosphatase 5 (PP5) is a novel human protein serine/threonine phosphatase of molecular weight of 58 kDa. It is made up of a C-terminal phosphatase catalytic domain and an N-terminal domain, which has four repeats of 34 amino acids, three of which are tandemly arranged. The phosphatase domain contains all of the invariant motifs of the PP1/PP2A/PP2B gene family. However, it is not closely related to any other known member of this family of phosphatases. Thus it makes up a new subfamily of phosphatases. PP5 expressed in bacteria has been shown to dephosphorylate serine residues in proteins and is more sensitive than PP1 to the tumor promoter okadaic acid. PP5 appears to be localized to the nucleus suggesting that, like other nuclear tetratricopeptide (TPR)-containing proteins, it may playa role in the regulation of RNA biogenesis and mitosis.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

See vial for concentration

Signal Transduction

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Western Blotting

Synthetic peptide derived from the human protein phosphatase 5 protein.

A549 and MCF-7 cell lysates

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Unconjugated

Products are stable for one year from purchase when stored properly

Ammonium Sulfate Precipitation

Rabbits were immunized with a Synthetic peptide derived from the human protein phosphatase 5 proteins

Serine/threonine-protein phosphatase 5 (EC 3.1.3.16) (PP5) (Protein phosphatase T) (PP-T) (PPT), PPP5C, PPP5

P53041 (Human)