Rabbit anti Human Adiponectin Receptor 2
| Code | Size | Price |
|---|
| EXA-X1699P | 100 ug | £442.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Shipping:
Ship at ambient temperature freeze upon arrival
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
Antibody can be used for Western blotting (5-10?g/ml) and ELISA. Other applications not yet tested. Cross reacts with Human ADR1. Optimal concentration should be evaluated by serial dilutions.
Background:
ADR2 functions as a receptor for globular and full-length adiponectin (APM1), which is an essential hormone secreted by adipocytes that acts as an antidiabetic. ADR2 is also probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. ADR2 mediates an increase in AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin and has some intermediate-affinity receptor activity for both globular and full-length adiponectin. ADR2 may form homo and heteromultimers.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Signal Transduction
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide near the C terminus of human adiponectin receptor 2 protein.
Positive Control:
Colon, Hippocampus, and Trachea
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Ammonium Sulfate Precipitation
Source:
Rabbits were immunized with a synthetic peptide near the C terminus of human adiponectin receptor 2 proteins
Synonyms:
Adiponectin receptor protein 2, Progestin and adipoQ receptor family member II, ADIPOR2, PAQR2
UniProt:
Q86V24
References
1. Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., , Marra M.A.; Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.; Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
2. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N.H., Shibata Y., Terauchi Y., Froguel P., , Kadowaki T.; Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.; Nature 423:762-769(2003).
2. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N.H., Shibata Y., Terauchi Y., Froguel P., , Kadowaki T.; Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.; Nature 423:762-769(2003).