Sheep anti Human ELK rec tyr Kinase (Eph B1 Cy.)

Applications: 1-10 ug/ml for Western Blotting and 10-20 ug/ml for immunoprecipitation.

The immunogen used for the anti-human ephB1 (Elk receptor) ?cytoplasmic(CY) region was a GST fusion protein ephB1 (Elk receptor) CY corresponding to amino acid sequence 586-984 of the C terminal, cytoplasmic region and having a molecular weight of 116 kDa. EphB1, previously known as Elk (eph-like kinase), is a receptor tyrosine kinase of the highly tissue restricted family of eph proteins. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. EphB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. EphB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cell-cell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

See vial for concentration

Signal Transduction

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Western Blotting

A GST fusion protein ephB1 (Elk receptor) - CY corresponding to amino acid sequence 586-984 of the C terminus region and having a molecular weight of 116 kDa

Human brain

Unconjugated

Antibodies are stable for one year from purchase if stored frozen

Ammonium Sulfate Precipitation

Eph B1 (ELK receptor) cytoplasmic; Tyrosine-protein kinase receptor EPH-2; Ephrin type B receptor 1; HEK6

P54762 (Human)