Nordic MuBio

Rabbit anti Human Calcium Channel

Product Code:
 
EXA-X2712P
Product Group:
 
Peptides
Supplier:
 
Nordic MuBio
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
Ship at ambient temperature freeze upon arrival
Storage:
 
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
 

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EXA-X2712P100 ug£316.00
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Further Information

Applications Description:
Antibody can be used for Western blotting (1:400 dilution). Optimal concentration should be evaluated by serial dilutions.
Background:
Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1b gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by omega-conotoxin-GVIA (omega-ctx-GVIA) and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to dihydropyridines (dhp), and omega-agatoxin-IVA (omega- aga-IVA). Calcium channels containing alpha-1b subunit may play a role in directed migration of immature neurons.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Signal Transduction
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide derived from the rat alpha1B calcium channel conjugated to KLH
Positive Control:
Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.
Product Form:
Affinity Purified
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Antigen Immunoaffiinity Purification
Synonyms:
Voltage-gated calcium channel subunit alpha Cav2.2, Calcium channel, L type, alpha-1 polypeptide isoform 5, Brain calcium channel III
UniProt:
Q00975

References

1. Dubel, S.J. et.al. 'Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel' Proc. Natl. Acad. Sci. U.S.A. 89 (11), 5058-5062 (1992)

2. Snutch,T.P.et.al. 'Rat brain expresses a heterogeneous family of calcium channels' Proc. Natl. Acad. Sci. U.S.A. 87 (9), 3391-3395 (1990)

3. Hell, J.W. et.al. 'Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini' J. Biol. Chem. 269 (10), 7390-7396 (1994)

4. Sunan, A.A. et.al. 'The C terminus of the Ca channel alpha1B subunit mediates selective inhibition by G-protein-coupled receptors.' J Neurosci. 21(19), 7587-97. (2001)