Rabbit anti Human Orexin Receptor-1 (N Terminal)

Antibody can be used for Western blotting at Optimal concentration should be evaluated by serial dilutions.

As first published in 1998 by Sakurai et al,, the initial neuropeptides Orexin A and Orexin B were shown to be important in the regulation of appetite. Continued research now suggests that these peptides also influence a wide range of physiological and behavioral processes such as increased EFG arousal and wakefulness and locomotor activity. In addition to the orexins , two G-protein coupled receptors, designated orexin receptor-1 and orexin receptor-2, have been identified which presumably mediate the signaling events from these neuropeptides1. Recently Orexin Receptors have been found to activate extracellular signal-regulated kinases in CHO cells, namely ERK phosporylation, through Ca2+ influx..2. Further studies seem to indicate a mechanism for orexin receptor mediated cell death and suggest a pathway from GPCR?s to apoptosis throughthe MAPK pathways.3

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

See vial for concentration

Signal Transduction

Immunoaffinity antibody povided as solution in phosphate buffered saline with 0.08% sodium azide

ELISA

Synthetic peptide made to the N terminal of human Orexin Receptor 1

membrane

Affinity Purified

Products are stable for one year from purchase when stored properly

Antigen Immunoaffiinity Purification

Ox1r, Hypocretin receptor type 1

O43613