Rabbit anti Human OGR1/GPR68
| Code | Size | Price |
|---|
| EXA-X1600P | 100 ug | £542.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Shipping:
Ship at ambient temperature freeze upon arrival
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
Antibody can be used for Western blotting (5-10 ?g/ml). Western blot should be visualized using a high sensitivity secondary/substrate system (i.e. Pierce?s SuperSignal West Femto Maximum Sensitivity Substrate). Optimal concentration should be evaluated by serial dilutions.
Background:
OGR1 (originally identified as GPR68) is a high-affinity receptor for sphingosylphosphorylcholine (SPC). SPC is a member of a class of bioactive lipids which regulate cellular functions. These functions include cell proliferation and growth inhibition, smooth muscle contration and wound healing. SPC also stimulated signalling pathways that induce tyrosine phosphorylation, activate MAP kinases and protein kinase C, modify ion channel activity and increase intracellular Ca2+ concentration. OGR1 is expressed in placenta, lung, liver, spleen, testis, small intestine and peripheral blood leukocytes. It is not found in thymus, ovary, colon, skeletal muscle, kidney or pancreas.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Signal Transduction
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Recombinant protein derived from human OGR1 (GPR68) protein
Positive Control:
OGR1 transfected cell lysate
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Protein A/G Chromatography
Source:
Rabbits were immunized with recombinant protein derived from human OGR1 (GPR68).
Synonyms:
GPR68; Ovarian Cancer G Protein-Coupled Receptor 1
UniProt:
Q15743
References
1. Xu, Y., et al. 'Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.' Nature Cell Biol., 2, 261-267 (2000)
2. Singh, L.S., et al. ?Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer.? J. Natl. Cancer Inst., 99, 1313-1327 (2007)
3. Yang, M., et al. ?Expression of and Role for Ovarian Cancer G-protein-coupled Receptor 1 (OGR1) during Osteoclastogenesis? J. Biol. Chem., 281, 23598-23605 (2006)
2. Singh, L.S., et al. ?Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer.? J. Natl. Cancer Inst., 99, 1313-1327 (2007)
3. Yang, M., et al. ?Expression of and Role for Ovarian Cancer G-protein-coupled Receptor 1 (OGR1) during Osteoclastogenesis? J. Biol. Chem., 281, 23598-23605 (2006)