Mouse anti Human p15 - ink4b

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Nordic MuBio
Product Code: EXA-C110M
Product Group: Primary Antibodies
Supplier: Nordic MuBio
CodeSizePrice
EXA-C110M100 ug£316.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: DCS114.1
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
Room Temperature
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Further Information

Applications Description:
Applications: 1-5 ug /ml for Western Blot, Immunohistochemistry, Immunoprecipitation (co-precipitates cdk4/cdk6)
Background:
The immunogen for the anti-human p15 was a his-tagged recombinant full length p15 protein recognizing a 15kDa protein. The p15ink4b tumor suppressor protein shows no cross reactivity with the closely related inhibitors including p16ink4a and p19ink4d. p15ink4b is a specific inhibitor of cdk4/cdk6, and is periodically expressed during cell cycle.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Cell Cycle
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
A his-tagged recombinant full length p15 protein recognizing a 15kDa protein
Product:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Ammonium Sulfate Precipitation
Source:
Mice were immunized with a his-tagged recombinant full length p15 protein recognizing a 15kDa protein
Synonyms:
hp15; p15 ink4b; Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2
UniProt:
P42772 (Human)

References

1) C. Sherr, et.al. (1995) Gene & Dev..9, 1149-1163

2) Sakellariou, S., et al. 'Immunohistochemical Expression of P15 (INK4B) and SMAD4 in Advanced Gastric Cancer.' Anticancer Research (2008), 28, 1079-1083