Mouse anti Human p16 - ink4a
| Code | Size | Price |
|---|
| EXA-C170M | 100 ug | £316.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: DCS50.1
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
Ship at ambient temperature freeze upon arrival
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
Applications: Western Blot, Immunoflurescence, Immunoprecipitation (co-precipitates cdk4/cdk6)
Background:
The immunogen for the anti-human p16 was a recombinant full length p16 protein recognizing a 16kDa protein. The p16ink4a tumor suppressor protein shows no cross reactivity with the closely related inhibitors such as p15ink4b and p18ink4c. p16ink4a is a specific inhibitor of cdk4/cdk6, and is a tumor suppressor involved in the pathogenesis of a number of malignancies including melanoma and lung carcinoma.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Cell Cycle
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
A recombinant full length p16 protein recognizing a 16kDa protein
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Protein A/G Chromatography
Synonyms:
hp16; p16 ink4a; Cyclin dependent kinase inhibitor 2A, isoforms 1/2/3; Cyclin-dependent kinase 4 inhibitor A; CDK4I
UniProt:
P42771 (Human)
References
1) J. Lukas et.al (1995) Nature., 375,503-506
2) L. Aagaard et.al. (1995), Intl. J. of Cancer 61(1) 115-120
2) L. Aagaard et.al. (1995), Intl. J. of Cancer 61(1) 115-120