Rabbit anti Rat calcium channel alpha2/delta subunit
| Code | Size | Price |
|---|
| EXA-X1512P | 100 ug | £316.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Rat
Shipping:
Ship at ambient temperature freeze upon arrival
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Further Information
Applications Description:
This antibody can be used for Western blotting (5-10 ?g/ml). Optimal concentration should be evaluated by serial dilutions.
Background:
The calcium channel alpha2/delta subunit is a glycosylated structural subunit consisting of the alpha2 subunit and the delta peptide. There is distinctive alpha2 subunit expression in rat spinal cord and dorsal root ganglia (DRG) There are two forms of the alpha2 subunit in DRG that are different from the alpha2 subunit in other tissues examined, at least at the glycosylation level. Thus, post-translational modification may be important in tissue specific and functional expression of the alpha2/delta subunit (2). alpha2/delta and beta1b interact with alpha1G to increase trafficking of, or stabilize, functional alpha1G channels expressed at the plasma membrane.(3)
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Signal Transduction
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide derived from the rat alpha2/delta calcium channel conjugated to KLH
Positive Control:
Rat brain lysate
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Ammonium Sulfate Precipitation
UniProt:
Q8VHS9
References
1. Kim, H.L et.al. 'Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit.' Proc. Natl. Acad. Sci. U.S.A. 89 (8), 3251-3255 (1992)
2. Luo, Z.D. 'Rat dorsal root ganglia express distinctive forms of the alpha2 calcium channel subunit.' Neuroreport.;11(16):3449-52 (2000)
3. Dolphin, AC et al. 'The effect of alpha2-delta and other accessory subunits on expression and properties of the calcium channel alpha1G.' J Physiol.;519 Pt 1:35-45.(1999)
2. Luo, Z.D. 'Rat dorsal root ganglia express distinctive forms of the alpha2 calcium channel subunit.' Neuroreport.;11(16):3449-52 (2000)
3. Dolphin, AC et al. 'The effect of alpha2-delta and other accessory subunits on expression and properties of the calcium channel alpha1G.' J Physiol.;519 Pt 1:35-45.(1999)