Lysophosphatidic Acid Receptor 1 CT (EDG-2)

For use with EDG2 (LPA1) (CT) polyclonal antibody (Cat. No. C174P).

Endothelial cell differentiation gene-2 (EDG2), or LPA1, receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG2 (LPA1), also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG2 (LPA1) is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG2 (LPA1) receptors (with EDG4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

See vial for concentration

Signal Transduction

Provided in solution at 1 mg/ml in phosphate buffered saline.

Western Blotting

Unconjugated

Products are stable for one year from purchase when stored properly

Blocking peptide for use in Western blotting with Anti-EDG2 (LPA1) (CT) (Cat. No. C174P)