anti-Isocitrate Dehydrogenase 1 [IDH1] (R132H Mutant) (human), mAb (AG-IHC132)

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AdipoGen Life Sciences
Product Code: AG-20B-6024
Product Group: Primary Antibodies
CodeSizePrice
AG-20B-6024-R100100 ul£170.00
Quantity:
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Overview

Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species: Human
Shipping:
Blue Ice (not freeze)
Storage:
+4°C

Images

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PD-1 receptor-induced CD4 T cell activation and proliferation by PD-1 (mouse), mAb (blocking) (1H10) (AG-20B-0075).Method: Magnetic bead affinity purified CD4+ T cells from C57BL/6 mice are stimulated in vitro with PD-1 (mouse), mAb (b
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PD-1 receptor-induced CD4 T cell activation and proliferation by PD-1 (mouse), mAb (blocking) (1H10) (AG-20B-0075).Method: Magnetic bead affinity purified CD4+ T cells from C57BL/6 mice are stimulated in vitro with PD-1 (mouse), mAb (b

Documents

Further Information

EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In Tris Buffer, pH 7.3 - 7.7, containing 1% BSA and <0.1% sodium azide.
Handling Advice:
Do not freeze.
Immunogen:
Synthetic IDH1 peptide.
Long Description:
Monoclonal Antibody. Recognizes human IDH1 mutated at R132H. Applications: ELISA, IHC. Isotype: Mouse IgG1. Clone: AG-IHC132. Liquid. In Tris Buffer, pH 7.4, containing 1% BSA and <0.1% sodium azide. Isocitrate Dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic cycle. The most notable mutation in this enzyme, R132H, is clinically indicated in the majority of astrocytomas and oligodendroglial tumors, with the mutation being associated with more favourable prognosis and increased survival in those patients. IDH1 R132H is also useful in the differential diagnosis between anaplastic glioma and glioblastoma. This antibody is intended to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. It has been optimized and validated using the BOND-MAX fully automated IHC&ISH stainer (see Protocol).
NCBI, Uniprot Number:
O75874
Package Type:
Plastic Vial
Product Description:
Isocitrate Dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic cycle. The most notable mutation in this enzyme, R132H, is clinically indicated in the majority of astrocytomas and oligodendroglial tumors, with the mutation being associated with more favourable prognosis and increased survival in those patients. IDH1 R132H is also useful in the differential diagnosis between anaplastic glioma and glioblastoma. This antibody is intended to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. It has been optimized and validated using the BOND-MAX fully automated IHC&ISH stainer (see Protocol).
Purity:
Protein A/G purified.
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes human IDH1 mutated at R132H.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C.

References

Consequences of IDH1/2 Mutations in Gliomas and an Assessment of Inhibitors Targeting Mutated IDH Proteins: B. Kaminska, et al. Molecules 24, E968 (2019) (Review)

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