Bim Antibody / BCL2L11

Western blot: 1:500-1:1000,Immunohistochemistry (FFPE): 1:50-1:100

Optimal dilution of the BCL2L11 antibody should be determined by the researcher.

The protein encoded by the BCL2L11 gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [RefSeq]

Purified

Antibody in PBS with 0.02% sodium azide and 50% glycerol

A synthetic peptide specific to human Bim / BCL2L11 was used as the immunogen for the Bim antibody.

This BCL2L11 antibody is available for research use only.

Affinity purified

Human

O43521