BUB1B Antibody / BubR1
| Code | Size | Price |
|---|
| NSJ-RQ4759-100ul | 100ul | £535.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Monoclonal
Antibody Clone: ABFG-2
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store the BUB1B antibody at -20°C.
Documents
Further Information
Application Details :
Western blot: 1:1000-1:5000
Application Note:
Optimal dilution of the BUB1B antibody should be determined by the researcher.
Description:
'Mitotic checkpoint serine/threonine-protein kinase BUB1 beta,' also called BubR1, is an essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [UniProt]
Format :
Purified
Formulation :
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Immunogen:
A synthetic peptide specific to human BUB1B was used as the immunogen for the BUB1B antibody.
Limitation:
This BUB1B antibody is available for research use only.
Purity:
Affinity purified
Species Reactivity :
Human
Uniprot #:
O60566