LGR5 Antibody / GPR49
| Code | Size | Price |
|---|
| NSJ-RQ4782-100ul | 100ul | £535.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Monoclonal
Antibody Clone: CHF-12
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store the GPR49 antibody at -20°C.
Documents
Further Information
Application Details :
Western blot: 1:500-1:2000
Application Note:
Optimal dilution of the GPR49 antibody should be determined by the researcher.
Description:
'G-protein coupled receptor 49,' or 'Leucine-rich repeat-containing G-protein coupled receptor 5' is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. [UniProt]
Format :
Purified
Formulation :
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Immunogen:
A synthetic peptide specific to human GPR49 / LGR5 was used as the immunogen for the GPR49 antibody.
Limitation:
This GPR49 antibody is available for research use only.
Purity:
Affinity purified
Species Reactivity :
Human
Uniprot #:
O75473