Thymidylate Synthase Antibody
| Code | Size | Price |
|---|
| NSJ-RQ5083-100ul | 100ul | £535.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Monoclonal
Antibody Clone: ADAA-20
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store the Thymidylate Synthase antibody at -20°C.
Documents
Further Information
Application Details :
Western blot: 1:500-1:2000
Application Note:
Optimal dilution of the Thymidylate Synthase antibody should be determined by the researcher.
Description:
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1, vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [RefSeq]
Format :
Purified
Formulation :
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Immunogen:
A synthetic peptide specific to human Thymidylate Synthase / TYMS was used as the immunogen for the Thymidylate Synthase antibody.
Limitation:
This Thymidylate Synthase antibody is available for research use only.
Purity:
Affinity purified
Species Reactivity :
Human
Uniprot #:
P04818