Insulin Receptor Antibody / INSR

Western blot: 1:1000-1:2000

Optimal dilution of the Insulin Receptor antibody should be determined by the researcher.

The INSR gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [RefSeq]

Purified

Antibody in PBS with 0.02% sodium azide and 50% glycerol

A synthetic peptide specific to human Insulin Receptor / INSR was used as the immunogen for the Insulin Receptor antibody.

This Insulin Receptor antibody is available for research use only.

Affinity purified

Human

P06213