Granzyme B Antibody

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NSJ Bioreagents
Product Code: NSJ-RQ5315
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-RQ5315-100ul100ul£535.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Monoclonal
Antibody Clone: AAHC-7
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry (IHC)
Storage:
Store the Granzyme B antibody at -20°C.

Images

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IHC staining of FFPE human T-cell lymphoma tissue with Granzyme B antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
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IHC staining of FFPE human T-cell lymphoma tissue with Granzyme B antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

Documents

Further Information

Application Details :
Immunohistochemistry (FFPE): 1:50-1:200
Application Note:
Optimal dilution of the Granzyme B antibody should be determined by the researcher.
Description:
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Format :
Purified
Formulation :
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Immunogen:
A synthetic peptide specific to human Granzyme B / GZMB was used as the immunogen for the Granzyme B antibody.
Limitation:
This Granzyme B antibody is available for research use only.
Purity:
Affinity purified
Species Reactivity :
Human
Uniprot #:
P10144