Amlodipine besylate
| Code | Size | Price |
|---|
| CDX-A0569-M010 | 10 mg | £94.00 |
Quantity:
| CDX-A0569-M050 | 50 mg | £340.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: n/a
Antibody Clone: n/a
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate; Norvasc; Amdepin; Amdipin; Amlodin
Appearance:
White to off-white powder.
CAS:
111470-99-6
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302
InChi:
InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChiKey:
ZPBWCRDSRKPIDG-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 111470-99-6. Formula: C20H25ClN2O5 . C6H5SO3H. MW: 567.05. Amlodipine is a long acting calcium channel antagonist that selectively inhibits calcium ion influx across cell membranes. It acts at the voltage gated calcium channel of the CaV1 or L-type class. It targets L-type calcium channels in muscle cells and N-type calcium channels in the central nervous system which are involved in nociceptive signalling and pain perception. Amlodipine is also an antihypertensive agent that inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in peripheral vascular resistance, thus lowering blood pressure. Its effects on cardiac muscle also prevent excessive constriction in the coronary arteries. Amlodipine has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.
MDL:
MFCD00887594
Molecular Formula:
C20H25ClN2O5 . C6H5SO3H
Molecular Weight:
567.05
Package Type:
Vial
Precautions:
P301 + P312 + P330
Product Description:
Amlodipine is a long acting calcium channel antagonist that selectively inhibits calcium ion influx across cell membranes. It acts at the voltage gated calcium channel of the CaV1 or L-type class. It targets L-type calcium channels in muscle cells and N-type calcium channels in the central nervous system which are involved in nociceptive signalling and pain perception. Amlodipine is also an antihypertensive agent that inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in peripheral vascular resistance, thus lowering blood pressure. Its effects on cardiac muscle also prevent excessive constriction in the coronary arteries. Amlodipine has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
NCCOCC1=C(C(OCC)=O)C(C2=C(Cl)C=CC=C2)C(C(OC)=O)=C(C)N1.O=S(C3=CC=CC=C3)(O)=O
Solubility Chemicals:
Soluble in DMSO (40 mg/ml), chloroform, ethanol, methanol or water (5mg/ml).
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) J.E. Arrowsmith, et al.; J. Med. Chem. 29, 1696 (1986) | (2) R.A. Burges, et al.; J. Cardiovasc. Pharmacol. 9, 110 (1987) | (3) G.A. Clavijo, et al.; Am. J. Hosp. Pharm. 51, 59 (1994) | (4) J. Yoshida, et al.; Eur. J. Pharmacol. 472, 23 (2003) | (5) R.P. Mason, et al.; Arterioscler. Thromb. Vasc. Biol. 23, 2155 (2003) | (6) H. Toba, et al.; Hypertens. Res. 28, 689 (2005)