Sulfo-NHS-LC-Biotin

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Chemodex
Product Code: CDX-B0310
Supplier: Chemodex
CodeSizePrice
CDX-B0310-M01010 mg£53.00
Quantity:
CDX-B0310-M05050 mg£169.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Antibody Isotype: n/a
Antibody Clone: n/a
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C

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Chemical Structure
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Chemical Structure

Documents

Further Information

Alternate Names/Synonyms:
EZ-Link Sulfo-NHS-LC-Biotin; Sulfosuccinimidyl 6-(biotinamido)hexanoate; Biotinamidohexanoic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt
Appearance:
White to off-white powder.
CAS:
191671-46-2 127062-22-0
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS08
Handling Advice:
Protect from light and moisture.
Hazards:
H360D
InChi:
InChI=1S/C20H30N4O9S2.Na/c25-15(7-4-3-6-13-18-12(11-34-13)22-20(29)23-18)21-9-5-1-2-8-17(27)33-24-16(26)10-14(19(24)28)35(30,31)32;/h12-14,18H,1-11H2,(H,21,25)(H2,22,23,29)(H,30,31,32);/q;+1/p-1/t12-,13-,14?,18-;/m0./s1
InChiKey:
JJGWLCLUQNFDIS-GTSONSFRSA-M
Long Description:
Chemical. CAS: 191671-46-2 127062-22-0. Formula: C20H29N4NaO9S2. MW: 556.59. Sulfo-NHS-LC-Biotin is an amino-reactive biotinylation reagent with a long spacer arm. The 6-aminocaproic acid spacer arm provides distance between the biotin and the target ligand which helps alleviate steric hindrance, in addition it forms permanent amide bonds. The sodium sulfonate groups render this compound water-soluble and prevent it from crossing the lipid bi-layer of the cell membrane, making it a tool to label cell surface proteins. In addition, Sulfo-NHS-LC-Biotin is used to biotinylate antibodies, proteins, peptides, or amino acids by reacting with primary amines as found in the N-terminus and Lysine side chains. Optimal reaction conditions are at a pH of 7-9. Avoid amine-containing buffers, which may compete in the acylation reaction.
MDL:
MFCD00078534
Molecular Formula:
C20H29N4NaO9S2
Molecular Weight:
556.59
Package Type:
Vial
Precautions:
P201-P308 + P313
Product Description:
Sulfo-NHS-LC-Biotin is an amino-reactive biotinylation reagent with a long spacer arm. The 6-aminocaproic acid spacer arm provides distance between the biotin and the target ligand which helps alleviate steric hindrance, in addition it forms permanent amide bonds. The sodium sulfonate groups render this compound water-soluble and prevent it from crossing the lipid bi-layer of the cell membrane, making it a tool to label cell surface proteins. In addition, Sulfo-NHS-LC-Biotin is used to biotinylate antibodies, proteins, peptides, or amino acids by reacting with primary amines as found in the N-terminus and Lysine side chains. Optimal reaction conditions are at a pH of 7-9. Avoid amine-containing buffers, which may compete in the acylation reaction.
Purity:
>90% (NMR)
SMILES:
O=C(NCCCCCC(ON1C(CC(S(=O)([O-])=O)C1=O)=O)=O)CCCC[C@@H]2SC[C@@]3([H])[C@]2([H])NC(N3)=O.[Na+]
Solubility Chemicals:
Soluble in water (10mg/ml), DMSO or DMF.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

(1) G.T. Hermanson; Bioconjugate Techn. 2nd p506-545 (2008)