Cabozantinib S-malate
| Code | Size | Price |
|---|
| CDX-C0698-M100 | 100 mg | £122.00 |
Quantity:
| CDX-C0698-M500 | 500 mg | £474.00 |
Quantity:
| CDX-C0698-G001 | 1 g | £779.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: n/a
Antibody Clone: n/a
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
XL184 malate; BMS907351 malate; N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-2-hydroxysuccinate
Appearance:
White to off white crystalline powder.
CAS:
1140909-48-3
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302, H315, H319, H335
InChi:
InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1
InChiKey:
HFCFMRYTXDINDK-WNQIDUERSA-N
Long Description:
Chemical. CAS: 1140909-48-3. Formula: C32H30FN3O10. MW: 635.59. The s-malate salt form of Cabozantinib is very potent orally available inhibitor of multiple receptor tyrosine kinases (RTK), specifically MET and VEGFR2. It also inhibits KIT, FLT3, Tie-2, RET and AXL. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature, angiogenesis and extensive tumor cell apoptosis.
MDL:
MFCD20923480
Molecular Formula:
C32H30FN3O10
Molecular Weight:
635.59
Package Type:
Vial
Precautions:
P264, P280, P301+P312, P302+P352, P305+P351+P338, P332+P313, P337+P313
Product Description:
The s-malate salt form of Cabozantinib is very potent orally available inhibitor of multiple receptor tyrosine kinases (RTK), specifically MET and VEGFR2. It also inhibits KIT, FLT3, Tie-2, RET and AXL. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature, angiogenesis and extensive tumor cell apoptosis.
Purity:
>99% (HPLC)
SMILES:
O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC(C=C3)=CC=C3OC4=CC=NC5=CC(OC)=C(OC)C=C54.O=C(O)C[C@H](O)C(O)=O
Solubility Chemicals:
Soluble in DMSO.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) R. Kurzrock, et al.; J. Clin. Oncol. 29, 2660 (2011) | (2) M. Yakes, et al.; Mol. Cancer Ther. 10, 2298 (2011) | (3) C. Hage, et al.; Cell Death Dis. 4, e627 (2013) | (4) F. Bentzien, et al.; Thyroid. 23, 1569 (2013) | (5) Y. Sun, et al.; Med. Sci. Monit. 21, 2316 (2015) | (6) J.N. Markowitz & K.M. Fancher; Pharmacotherapy 38, 357 (2018) | (7) C. Gruellich; Recent Results Cancer Res. 211, 67 (2018)