Levocetirizine dihydrochloride
| Code | Size | Price |
|---|
| CDX-L0121-M010 | 10 mg | £55.00 |
Quantity:
| CDX-L0121-M050 | 50 mg | £181.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: n/a
Antibody Clone: n/a
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
(R)-Cetirizine dihydrochloride; (-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride
Appearance:
Solid.
CAS:
130018-87-0
Class:
9
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07,GHS09
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H400
InChi:
InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1./s1
InChiKey:
PGLIUCLTXOYQMV-GHVWMZMZSA-N
Long Description:
Chemical. CAS: 130018-87-0. Formula: C21H25ClN2O3 . 2HCl. MW: 461.81. Levocetirizine hydrochloride is the (R)-enantiomer of the histamine H1 receptor antagonist and antihistamine agent cetirizine. It binds to the H1 receptor with higher affinity than cetirizine and is 25,000-100,000-fold selective for H1 receptors over muscarinic M1-M5 receptors. Intranasal administration dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice. Has been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.
MDL:
MFCD07366507
Molecular Formula:
C21H25ClN2O3 . 2HCl
Molecular Weight:
461.81
Package Type:
Vial
PG:
III
Precautions:
P273
Product Description:
Levocetirizine hydrochloride is the (R)-enantiomer of the histamine H1 receptor antagonist and antihistamine agent cetirizine. It binds to the H1 receptor with higher affinity than cetirizine and is 25,000-100,000-fold selective for H1 receptors over muscarinic M1-M5 receptors. Intranasal administration dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice. Has been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
ClC(C=C1)=CC=C1[C@@H](C2=CC=CC=C2)[NH+]3CC[NH+](CCOCC(O)=O)CC3.[Cl-].[Cl-]
Solubility Chemicals:
Soluble in water (20mg/ml).
Source / Host:
Synthetic.
Transportation:
Excepted Quantity
UN Nummer:
3077
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) M. Gillard, et al.; Inflamm. Res. 52, S49 (2003) | (2) L. Zhang, et al.; Pharmacol. 92, 14 (2013) | (3) C. Kitayama-Sugiyama, et al.; Immunotoxicol. 35, 545 (2013) | (4) A. Kanei, et al.; In Vivo 28, 657 (2014)