Naproxen solution 1.0 mg/ml in methanol

Chemodex
Product Code: CDX-N0258
Supplier: Chemodex
CodeSizePrice
CDX-N0258-L0055 ml£78.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C

Images

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Chemical Structure

Chemical Structure

Further Information

Alternate Names/Synonyms:
(S)-Naproxen; (+)-Naproxen; (S)-(+)-6-Methoxy-alpha-methyl-2-naphthalene acetic acid; Equiproxen; Laraflex
Appearance:
Liquid. 1mg/ml in methanol.
CAS:
22204-53-1
Class:
3
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS02,GHS06
Handling Advice:
Protect from light and moisture.
Hazards:
H225-H301 + H311 + H331-H370
InChi:
InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
InChiKey:
CMWTZPSULFXXJA-VIFPVBQESA-N
Long Description:
Chemical. CAS: 22204-53-1. Formula: C14H14O3. MW: 230.26. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory cyclooxygenase (COX-1 and COX-2) inhibitor. Inhibits COX-1 expression in HUVECS at a concentration of 5µg/ml. This COX inhibitor is indicated for the treatment of pain, fever, inflammation and stiffness. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block A? fibril growth and form a complex with copper (II).
MDL:
MFCD00010500
Molecular Formula:
C14H14O3
Molecular Weight:
230.26
Package Type:
Vial
PG:
III
Precautions:
P210-P260-P280-P301 + P310-P311
Product Description:
Naproxen is a potent, non-steroidal, non-selective anti-inflammatory cyclooxygenase (COX-1 and COX-2) inhibitor. Inhibits COX-1 expression in HUVECS at a concentration of 5µg/ml. This COX inhibitor is indicated for the treatment of pain, fever, inflammation and stiffness. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block A? fibril growth and form a complex with copper (II).
Purity:
>98% (HPLC)
Signal Word:
Danger
SMILES:
C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1
Solubility Chemicals:
Soluble in aqueous buffers.
Source / Host:
Synthetic.
Transportation:
Excepted Quantity
UN Nummer:
1230
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

References

(1) W.F. Kean, et al.; J. Pharm. Sci. 78, 324 (1989) | (2) T. Zyglewska, et al.; Biochim. Biophys. Acta 1131, 78 (1992) | (3) J. Barnett, et al.; Biochim. Biophys. Acta 1209, 130 (1994) | (4) O. Laneuville, et al.; J. Pharmacol. Exp. Ther. 271, 927 (1994) | (5) N.M. Davies & K.E. Anderson; Clin. Pharmacokinet. 32, 268 (1997) | (6) N. Monck; IDrugs 6, 593 (2003) | (7) T. Takeda, et al.; J. Phys. Chem. B. 114, 15394 (2010) | (8) K.C. Duggan, et al.; J. Biol. Chem. 285, 34950 (2010)