Olanzapine
| Code | Size | Price |
|---|
| CDX-O0143-G001 | 1 g | £96.00 |
Quantity:
| CDX-O0143-G005 | 5 g | £353.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: n/a
Antibody Clone: n/a
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine; LY-170053
Appearance:
Yellow powder.
CAS:
132539-06-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315-H319-H413
InChi:
InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
InChiKey:
KVWDHTXUZHCGIO-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 132539-06-1. Formula: C17H20N4S. MW: 312.43. Olanzapine is a 5-HT2 serotonin and D1/D2 dopamine receptor antagonist, that binds to dopamine D1, D2, and D4 receptors (Ki=31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C and 5-HT3 (Ki=4, 11, and 57 nM, respectively). It also binds to M1 muscarinic acetylcholine, alpha1-adrenergic and histamine H1 receptors (Ki=2, 19, and 7 nM, respectively). Olanzapine is an atypical antipsychotic that displays anticholinergic properties. Olanzapine shows antidepressant-like activity. Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder and for the prevention and treatment of chronic nausea and chemotherapy-induced nausea and vomiting.
MDL:
MFCD00866702
Molecular Formula:
C17H20N4S
Molecular Weight:
312.43
Package Type:
Vial
Precautions:
P305 + P351 + P338
Product Description:
Olanzapine is a 5-HT2 serotonin and D1/D2 dopamine receptor antagonist, that binds to dopamine D1, D2, and D4 receptors (Ki=31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C and 5-HT3 (Ki=4, 11, and 57 nM, respectively). It also binds to M1 muscarinic acetylcholine, alpha1-adrenergic and histamine H1 receptors (Ki=2, 19, and 7 nM, respectively). Olanzapine is an atypical antipsychotic that displays anticholinergic properties. Olanzapine shows antidepressant-like activity. Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder and for the prevention and treatment of chronic nausea and chemotherapy-induced nausea and vomiting.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
CN(CC1)CCN1C2=NC(C=CC=C3)=C3NC4=C2C=C(C)S4
Solubility Chemicals:
Soluble in DMSO (10mg/ml) or DMF.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) N.A. Moore, et al.; J. Pharmacol. Exp. Ther. 262, 545 (1992) | (2) F.P. Bymaster, et al.; Neuropsychopharmacol. 14, 87 (1996) | (3) G.D. Tollefson & C.C. Taylor; CNS Drug Reviews 6, 303 (2000) | (4) E. Nowakowska, et al.; Pharmacol. Rep. 66, 404 (2014) | (5) D.M. Ashby, et al.; Behav. Pharmacol. 26, 133 (2015) | (6) C. Fonte, et al.; Crit. Rev. Oncol. Hematol. 95, 214 (2015)