Pyridoxal 5'-phosphate monohydrate
| Code | Size | Price |
|---|
| CDX-P0461-G005 | 5 g | £72.00 |
Quantity:
| CDX-P0461-G025 | 25 g | £242.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: n/a
Antibody Clone: n/a
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
P5P; PLP; Codecarboxylase; 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde; Pyridoxal 5-phosphate; Vitamin B6 Metabolite
Appearance:
White to off-white powder.
CAS:
41468-25-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2
InChiKey:
CEEQUQSGVRRXQI-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 41468-25-1. Formula: C8H10NO6P . H2O. MW: 265.16. The enzyme cofactor Pyridoxal-5'-phosphate monohydrate is a vitamin B6 metabolite that can modify lysyl and valyl residues in proteins. It acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. It has the ability to inhibit purinergic receptors and intracellular influx of Ca2+. Pyridoxal-5'-phosphate monohydrate can modify peptides and suppress their precursor ionization efficiency. Research shows that pyridoxal-5'-phosphate-dependent enzymes can be inhibited by cycloserine.
MDL:
MFCD00006333
Molecular Formula:
C8H10NO6P . H2O
Molecular Weight:
265.16
Package Type:
Vial
Product Description:
The enzyme cofactor Pyridoxal-5'-phosphate monohydrate is a vitamin B6 metabolite that can modify lysyl and valyl residues in proteins. It acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. It has the ability to inhibit purinergic receptors and intracellular influx of Ca2+. Pyridoxal-5'-phosphate monohydrate can modify peptides and suppress their precursor ionization efficiency. Research shows that pyridoxal-5'-phosphate-dependent enzymes can be inhibited by cycloserine.
Purity:
>99% (HPLC)
SMILES:
O=C([H])C1=C(O)C(C)=NC=C1COP(O)(O)=O.[H]O[H]
Solubility Chemicals:
Slightly soluble in water.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) D.E. Kandzari, et al.; Am. J. Cardiol. 92, 660 (2003) | (2) D.W. Kim, et al.; J. Biochem. Mol. Biol. 38, 58 (2005) | (3) J.C. Tardif, et al.; J. Thorac. Cardiovasc. Surg. 133, 1604 (2007) | (4) M. Neuwirth, et al.; FEBS Lett. 583, 2179 (2009) | (5) E.S. Simon, et al.; Rapid Commun. Mass Spectrom 23, 3401 (2009) | (6) J. Lowther, et al.; Mol Biosyst. 6, 1682 (2010) | (7) J.L. Hedrick; Adv. Biochem. Psychopharmacol. 4, 23 (1972) | (8) B.I. Yang & D.E. Metzler; Methods Enzymol. 62, 528 (1979) | (9) G. Tunnicliff & T.T. Ngo; Cell Physiol. Biochem. 8, 117 (1998) | (10) P. Christen & P.K. Mehta; Chem. Rec. 1, 436 (2001) | (11) M.L. di Salvo, et al.; Front. Biosci 4, 897 (2012) | (12) L. Paul, et al.; Nutr. Rev. 71, 239 (2013)