Sertraline hydrochloride
| Code | Size | Price |
|---|
| CDX-S0088-M010 | 10 mg | £72.00 |
Quantity:
| CDX-S0088-M050 | 50 mg | £255.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: n/a
Antibody Clone: n/a
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride; CP 51,974-1; Lustral; Seserine; Zoloft
Appearance:
White to off-white powder.
CAS:
79559-97-0
Class:
9
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07,GHS09
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H400
InChi:
InChI=1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChiKey:
BLFQGGGGFNSJKA-XHXSRVRCSA-N
Long Description:
Chemical. CAS: 79559-97-0. Formula: C17H17NCl2 . HCl. MW: 342.69. Sertraline is a tetraline that inhibits monoamine transporters and acts as a potent highly selective serotonin reuptake inhibitor (SSRI), with affinity for the serotonin transporter (SERT), increasing availability of serotonin (5-hydroxytryptamine; 5-HT) in the brain and leading to antidepressant, anxiolytic and antiobsessional effects. Sertraline binds also to the dopamine transporter (DAT) and the sigma1 receptor (but not the sigma2 receptor) with 100-fold lower affinity. It acts as an antagonist of the sigma1 receptor, and is able to reverse sigma1 receptor-dependent actions of fluvoxamine, a potent agonist of the receptor, in vitro. Sertraline displays antiproliferative activity on human colorectal carcinoma cells.
MDL:
MFCD00895772
Molecular Formula:
C17H17NCl2 . HCl
Molecular Weight:
342.69
Package Type:
Vial
PG:
III
Precautions:
P301 + P312 + P330
Product Description:
Sertraline is a tetraline that inhibits monoamine transporters and acts as a potent highly selective serotonin reuptake inhibitor (SSRI), with affinity for the serotonin transporter (SERT), increasing availability of serotonin (5-hydroxytryptamine; 5-HT) in the brain and leading to antidepressant, anxiolytic and antiobsessional effects. Sertraline binds also to the dopamine transporter (DAT) and the sigma1 receptor (but not the sigma2 receptor) with 100-fold lower affinity. It acts as an antagonist of the sigma1 receptor, and is able to reverse sigma1 receptor-dependent actions of fluvoxamine, a potent agonist of the receptor, in vitro. Sertraline displays antiproliferative activity on human colorectal carcinoma cells.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
ClC(C=C1)=C(Cl)C=C1[C@H]2C3=C(C=CC=C3)[C@@H]([NH2+]C)CC2.[Cl-]
Solubility Chemicals:
Soluble in DMSO (20mg/ml) or ethanol (10mg/ml).
Source / Host:
Synthetic.
Transportation:
Excepted Quantity
UN Nummer:
3077
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) B.K. Koe, et al.; J. Pharmacol. Exp. Ther. 226, 686 (1983) | (2) W.M. Welch, et al.; J. Med. Chem. 27, 1508 (1984) | (3) J. Heym & B.K. Koe; J. Clin. Psychiatry 49, 40 (1988) | (4) M. Tatsumi, et al.; Eur. J. Pharmacol. 340, 249 (1997) | (5) G. MacQueen, et al.; CNS Drug Reviews 7, 1 (2001) | (6) H.R. Khouzam, et al.; Compr. Ther. 29, 47 (2003) | (7) J.H. Meyer, et al.; Am. J. Psych. 161, 826 (2004) | (8) B. Lowe, et al.; J. Affect. Disord. 87, 271 (2005) | (9) Y. Albayrak & K. Hashimoto; Adv. Exp. Med. Biol. 964, 153 (2017)