LRP5 Antibody

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ProSci
Product Code: PSI-13-045
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-13-045-50uL50uL£433.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Shipping:
Blue Ice or RT
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western blot analysis of extracts of various cell lines, using LRP5 antibody (13-045) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.<br/>Detection: ECL Basic Kit.<br/>Exposure time: 90s.
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Immunohistochemistry of paraffin-embedded human liver using LRP5 antibody (13-045) at dilution of 1:200 (40x lens).
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Immunohistochemistry of paraffin-embedded human prostate using LRP5 antibody (13-045) at dilution of 1:200 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse lung using LRP5 antibody (13-045) at dilution of 1:200 (40x lens).
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Western blot analysis of extracts of various cell lines, using LRP5 antibody (13-045) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.<br/>Detection: ECL Basic Kit.<br/>Exposure time: 90s.
Immunohistochemistry of paraffin-embedded human liver using LRP5 antibody (13-045) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human prostate using LRP5 antibody (13-045) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded mouse lung using LRP5 antibody (13-045) at dilution of 1:200 (40x lens).

Documents

Further Information

Additional Names:
LRP5, low density lipoprotein receptor-related protein 5, HGNC:6697, BMND1, HBM, LR3, LRP7, OPPG, OPS, VBCH2, low density lipoprotein receptor-related protein 7, osteoporosis pseudoglioma syndrome
Application Note:
WB: 1:500 - 1:2000

IHC: 1:50 - 1:200
Background:
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1250 of human LRP5 (NP_002326.2).
NCBI Gene ID #:
4041
NCBI Official Name:
low density lipoprotein receptor-related protein 5
NCBI Official Symbol:
LRP5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 150kDa
Purification:
Affinity purification
Research Area:
Cancer, Cell Cycle, Neuroscience, Signal Transduction, Stem Cell
Swissprot #:
O75197
User NOte:
Optimal dilutions for each application to be determined by the researcher.