DCX Antibody

Contact us
ProSci
Product Code: PSI-13-054
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-13-054-100uL100uL£541.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Shipping:
Blue Ice or RT
Storage:
Store at 4°C. Avoid freeze / thaw cycles.

Images

1 / 1
Western blot analysis of extracts of mouse brain, using DCX antibody (13-054).<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.
❮❯

Western blot analysis of extracts of mouse brain, using DCX antibody (13-054).<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.

Documents

Further Information

Additional Names:
neuronal migration protein doublecortin, lissencephalin-X, lis-X, doublin, doublecortex, OTTHUMP00000216316, XLIS, SCLH, LISX, FLJ51296, DC, DBCN, RP5-914P14.1, doublecortin, DCX
Application Note:
WB: 1:500 - 1:1000

IHC: 1:20 - 1:50
Background:
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.02% sodium azide, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A synthetic peptide of human DCX
NCBI Gene ID #:
1641
NCBI Official Name:
doublecortin
NCBI Official Symbol:
DCX
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 41kDa
Purification:
Affinity purification
Research Area:
Cell Cycle, Neuroscience
Swissprot #:
O43602
User NOte:
Optimal dilutions for each application to be determined by the researcher.