ABL1 Antibody

Abelson tyrosine-protein kinase 2, Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine-protein kinase ARG, ABL2, ABLL, ARG

WB: 1:500 - 1:2000

IHC: 1:100 - 1:200

IF: 1:50 - 1:200

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

A synthetic peptide corresponding to a sequence within amino acids 490-590 of human ABL1 (NP_005148.2).

25

Tyrosine-protein kinase ABL1

ABL1

Homo sapiens

Liquid

Observed: 139kDa

Affinity purification

Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction

P00519

Optimal dilutions for each application to be determined by the researcher.