DUSP6 Antibody
| Code | Size | Price |
|---|
| PSI-13-231-100uL | 100uL | £541.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Shipping:
Blue Ice or RT
Storage:
Store at 4°C. Avoid freeze / thaw cycles.
Documents
Further Information
Additional Names:
DUSP6, dual specificity phosphatase 6, MKP3, PYST1, MAP kinase phosphatase 3, dual specificity protein phosphatase 6, dual specificity protein phosphatase PYST1, mitogen-activated protein kinase phosphatase 3, serine/threonine specific protein phosphatase
Application Note:
WB: 1:500 - 1:1000
IF: 1:20 - 1:50
IF: 1:20 - 1:50
Background:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
Buffer:
PBS with 0.02% sodium azide, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A synthetic peptide of human DUSP6
NCBI Gene ID #:
1848
NCBI Official Name:
dual specificity phosphatase 6
NCBI Official Symbol:
DUSP6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 45kDa
Purification:
Affinity purification
Research Area:
Immunology, Neuroscience, Signal Transduction
Swissprot #:
Q16828
User NOte:
Optimal dilutions for each application to be determined by the researcher.