IGF2R Antibody

IGF2R, CD222 antigen, CIMPR, CI Man-6-P receptor, CI-MPR, IGF-II receptor, MPR 300, MPR1, MPRI, M6P-R, M6P/IGF2R, CD222, M6P/IGF2 receptor

WB: 1:500 - 1:2000

IHC: 1:50 - 1:200

IF: 1:50 - 1:200

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Recombinant fusion protein containing a sequence corresponding to amino acids 2327-2491 of human IGF2R (NP_000867.2).

3482

insulin-like growth factor 2 receptor

IGF2R

Homo sapiens

Liquid

Observed: 310kDa

Affinity purification

Immunology, Innate Immunity, Signal Transduction

P11717

Optimal dilutions for each application to be determined by the researcher.