TNFRSF1B Antibody

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ProSci
Product Code: PSI-15-066
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-15-066-50uL50uL£433.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Shipping:
Blue Ice or RT
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western blot analysis of extracts of mouse liver, using TNFRSF1B antibody (15-066) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.
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Immunohistochemistry of paraffin-embedded rat kidney using TNFRSF1B antibody (15-066) at dilution of 1:200 (40x lens).
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Immunohistochemistry of paraffin-embedded human lung cancer using TNFRSF1B antibody (15-066) at dilution of 1:200 (40x lens).
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Immunohistochemistry of paraffin-embedded human rectal cancer using TNFRSF1B antibody (15-066) at dilution of 1:200 (40x lens).
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Western blot analysis of extracts of mouse liver, using TNFRSF1B antibody (15-066) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.
Immunohistochemistry of paraffin-embedded rat kidney using TNFRSF1B antibody (15-066) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human lung cancer using TNFRSF1B antibody (15-066) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human rectal cancer using TNFRSF1B antibody (15-066) at dilution of 1:200 (40x lens).

Documents

Further Information

Additional Names:
p75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B, TNFR80, TNF-R75, p75TNFR, TNF-R-II, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, TNF-R2
Application Note:
WB: 1:500 - 1:2000

IHC: 1:50 - 1:200
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-250 of human TNFRSF1B (NP_001057.1).
NCBI Gene ID #:
7133
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 1B
NCBI Official Symbol:
TNFRSF1B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 60kDa
Purification:
Affinity purification
Research Area:
Apoptosis, Cancer, Cell Cycle, Chemokines & Cytokines, Growth Factors, Immunology, Innate Immunity, Neuroscience, Signal Transduction
Swissprot #:
P20333
User NOte:
Optimal dilutions for each application to be determined by the researcher.