NR3C1 Antibody

NR3C1, GR, GCR, GRL, GCCR

WB: 1:500 - 1:2000

IF: 1:50 - 1:200

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human NR3C1 (NP_001191194.1).

2908

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

NR3C1

Homo sapiens

Liquid

Observed: 105kDa

Affinity purification

Signal Transduction, Transcription

P04150

Optimal dilutions for each application to be determined by the researcher.