DCX Antibody

neuronal migration protein doublecortin, lissencephalin-X, lis-X, doublin, doublecortex, OTTHUMP00000216316, XLIS, SCLH, LISX, FLJ51296, DC, DBCN, RP5-914P14.1, doublecortin, DCX

WB: 1:500 - 1:2000

IF: 1:50 - 1:200

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Recombinant fusion protein containing a sequence corresponding to amino acids 240-360 of human DCX (NP_835364.1).

1641

doublecortin

DCX

Homo sapiens

Liquid

Affinity purification

Cell Cycle, Neuroscience

O43602

Optimal dilutions for each application to be determined by the researcher.